Selecting the Right Syringe for Your Application

ILS Syringe Selection Guide

What to take into consideration when selecting syringes?

Although the syringes are built-in an uncomplicated way, depending on the application, the same parts can have multiple variants. Locks, tapers, plungers, tips and other parts are selected primarily by the type of medium that the product will be used. It is because each element must resist the type of liquid that will go through the syringe.

There are two types of models produced – with a fixed needle or removable needle. Syringes with a removable needle are recommended for the inexperienced users. Though they are not as cost-effective as the one with fixed needles, as it’s easier and more reasonable to replace just the needle if it bends, not the entire syringe. That will leverage a cost reduction over time if used by novice users.

Syringes with a fixed needle, on the other hand, are recommended for experienced operators. They are a preferred choice for autosampler and other applications, where the risk of needle bending is minimal, as well as for most accurate trace sample levels. The foremost advantage of the fixed needle is the fact that it is cemented into the barrel, leaving no gap. Thanks to that, there is no risk of sample carryover or cross-contamination. Fixed needle syringes are more economical than the ones with removable needles.

Needles Types

You can choose between two needle types – fixed or removable.

Removable needle: The needle can be removed and replaced by a new one in case the needle is bent or damaged. These syringes are autoclavable.

Fixed needle: The needle is attached to the glass barrel and cannot be removed. These syringes are not autoclavable, but have the least carryover.

There are also different tip styles you can choose from depending on the requirements of your application.

needle tip style tip a

Needle Tip “a”

This tip is designed for optimum penetration of the septa and prevents septa coring.
The 17° bevel is proven standard. In addition our electro tapered tip minimizes the necessary piercing force and diameter of the injection channel.
needle tip style tip b

Needle Tip “b”

This tip has a 90° bevel for precise pipetting. This design releases drops completely, for maximum reproducibility. It is widely used for HPLC sample injection.
needle tip style tip c

Needle Tip “c”

This tip has been specially designed for autosamplers in routine applications.
The electro tapered tip and the polished 90° square end eliminate burrs. It is ideal for PTFE laminated seals and regular septas.
needle tip style tip c star

Needle Tip “c**”

Dual gauge – Narrow gauge at front end for on-column injection and wide gauge to increase strength for autosampler use.
needle tip style tip d

Needle Tip “d”

Tip “d” is equipped with a side opening for dispensing and filling.
This design avoids plugging and minimizes septum damage. It is ideal for thicker septa and recommended for headspace analysis.

Types of Syringe Plungers and Seals

The standard dispensing syringes come with various types of plungers that differ in regard to the application.

Plunger rod can have an additional seal mounted at the top of the end of the syringe barrel. The seal at the headspace provides the leak-proof sealing between plunger and syringe barrel. The sealing affords the user to gain better control over dosing and smoother injection. It is also necessary for dispensing of gas.

Types of Syringe Taper

Luer taper is an industry-standard for small-scale fluid fittings used for making leak-free connections. Luer fittings are available in two types - as Luer Lock Tip and regular Luer Trip. The main difference between them is the fitting principle for the needle or medical and laboratory instrument.

The syringes with Luer Lock require a twisted connection between a male-taper fitting and its corresponding female part instruments or in the syringe needles. The twisted connection guarantees no leakage and prevents accidental removal of the needles.

The needles of syringes with regular Luer tip are slipped on firmly, as there’s no locking mechanism. Hence, they’re quicker to fit.

The needles with Luer fitting are compatible both with the Luer Slip tip and Luer Lock fittings.

Syringe Plunger Seals

The seal provides leak-proof sealing between the plunger and the syringe barrel. Depending on the medium you are using in the syringe, ILS offers different types of seal materials that you can choose from with different kinds of chemical resistance and abrasiveness.

plunger seal ptfe seal

Virginal PTFE

High chemical resistance
plunger seal ptfe black seal

Special PTFE

High chemical resistance
Less friction than virgin PTFE
Less electronic charge
Higher robustness
Less "cold flow"
Higher longevity
Order Information: Add "BL" to catalog number (XXXXXXX-BL)
plunger seal pe hd seal

Polyethylene High Density

Better durability than virginals PTFE when working with saline solution

Syringe Selection Guide

How to select the right syringe for your application or instrument?

Series N – standard glass syringes for liquids

It features the most popular plunger crafted for a liquid dispensing and made from stainless steel.

It is exceptionally tightly fitted into the glass barrel what is the desired solution for dispensing liquids. The stainless steel plunger rod is well-mounted in the barrel, to allow for exact dosing. It is fixed and thus cannot be replaced.

Series H – gas tight micro syringes

H series features seals made from PTFE or PE.

The PTFE is a standard seal material. It is most commonly known as Teflon® or polytetrafluorethylene. PTFE plunger topping provides a gas tight sealing for the headspace, which makes it applicable for dispensing both liquids and gas.

PE-HD Seals provide better durability than PTFE when working with salty solutions. High-density polyethylene is well-known for its low coefficient of friction which provides smooth operations. HDPE materials durability against impact and abrasion.

Series P – micro syringes with adjustable seal

For gas chromatography and HPLC valves, ILS delivers syringes with adjustable PTFE seals. They are equipped with screws that enable regulation of seal-pressure. Adjustable PTFE seals give the user control over increasing or decreasing of the seal pressure according to dosage requirements.

Series G – micro syringes with an additional seal at the topping

For applications and equipment that requires dosage under counter pressures, ILS provides Static PTFE-Seal at the top of the glass barrel for an additional seal at the topping.

Series T - Zero Dead Volume micro syringes

Whenever a superior accuracy in a small dosage of liquid is required, a syringe with zero dead volume design is the best solution. In the T series plunger also runs inside the needle, allowing for dosage as low as 1 microliter.

Series SN/SH – glass syringes with extended handle

Specialized construction of the plunger prevents the content from being heated by the hand of the user. The plunger rod is designed in a way that protects it from bending. Both the SH and SN series find application for gas chromatography and HPLC valves

fixed needles

Fixed Needles (FN)

  • easy to use
  • economical
  • not autoclavable
removable needles

Removable Needles (RN)

  • for unexperienced users
  • easy to replace in case of bending
  • use of different needle sizes on the same syringe barrel
stainless steel plunger

Stainless Steel Plunger N

  • for dispensing of liquids
  • plunger individually fitted to glass barrel
  • plunger not replaceable
ptfe seal h


  • for dispensing of gas and liquids, headspace
  • gas tight
  • plunger replaceable
pe hd seal

PE-HD Seal

  • for buffer and other aqueous solutions
  • for smoother operation
  • plunger replaceable
adjustable ptfe seal

Adjustable PTFE-Seal P

  • for gas chromatography and HPLC valves
  • dosage under pressure
  • regulation of seal-pressure by screws
glass luer tip lt

Glass Luer Tip LT

  • for sample dosage
  • dosage of aggressive fluids
  • autoclavable
ptfe luer tip tlt


  • for sample dosage
  • dosage of aggressive fluids
  • for luer lock needles and fittings
luer lock tll

Luer Lock TLL

  • for sample dosage, diluters and dispensers
  • dosage of aggressive fluids
  • for luer hub needles and connectors
zero dead volumem

Zero Dead Volumem T

  • for gas chromatography and TLC
  • dosage of small amounts of liquids
  • plunger runs inside the needle
extended handle sn

Extended Handle SN / SH

  • for gas chromatography and HPLC valves
  • prevents heat transfer from hand to content
  • protects plunger from bending
static ptfe seal topping the glass barrel

Static PTFE-Seal Topping the Glass Barrel G

  • for gas chromatography
  • HPLC valves
  • dosage under counter-pressure

Range of ILS Syringes

ILS offers over 1000 types and variations of glass syringes. The complete manufacturing process is done in-house. In addition to great engineering expertise, we offer unique possibilities of customized solutions to match the individual needs of our customers.

ILS product range focuses on two types of glass syringes – designed for use in syringe pumps and the analytical one for use in various lab instruments and liquid handling applications.

Analytical Syringes

Analytical syringes are used in laboratory instruments for analytical applications such as gas and liquid chromatography or mass spectrometry. They are usually equipped with a needle and the volume size ranges from 100µL to 5ml.

Compatible with Syringe Pumps

ILS offers glass syringes for syringe pumps that are part of liquid handling instruments. They are an industry standard product compatible with all common syringe pumps from different manufacturers. The volume size ranges from 0.5 ml up to 25 ml.

ILS syringes for dispensing or diluting liquid is also fully compatible with the instruments from Hamilton, Trajan/SGE, Koehn/IMI, as well as other manufacturers - Tecan, Thermo Fisher Scientific, Agilent, ITO, Perkin Elmer, Waters, Setonic, MK Fluidics, Flex Fluidics, Vici and Zinsser Analytic.